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Contrast Reactions Guide

For all cases

  • Always follow BLS and ACLS Guidelines as indicated and most importantly, your clinical judgement
  • Remember your ABCs (Airway, Breathing, Circulation)
  • Call for help (EMT/code team) immediately if necessary
  • Whenever epinephrine is administered, consider cardiac contraindications
  • For pediatric patients, remember appropriate medication dosing (typically weight based)

Urticaria

  • Discontinue contrast administration
  • Usually, no treatment needed
  • Mild to Moderate Reaction: Benadryl 25-50 mg PO/IM/IV (adult dosing); advise patient not to drive home alone after treatment; Pediatric Dose is 1 mg/kg up to 50 mg
  • Severe Reaction: Epinephrine SC (1:1000) 0.1-0.3 mL (equivalent to a dose of 0.1-0.3 mg)

Facial or Laryngeal Edema

  • Oxygen (6-10L/min)
  • Epinephrine SC (1:1000) 0.1-0.3mL (equivalent to 0.1-0.3mg)
  • If hypotension, give Epinephrine (1:10,000) 1mL slowly IV (equivalent to 0.1mg) and up to 1 mg as needed

Bronchospasm

  • Oxygen (6-10L/min)
  • Give beta agonist inhalers (Albuterol, bronchodilators)
  • Epinephrine SC (1:1000) 0.1-0.3mL (equivalent to 0.1-0.3mg)
  • If hypotension, give Epinephrine (1:10,000) 1mL slowly IV (equivalent to 0.1mg) and up to 1 mg as needed
  • Alternatively: Aminophylline 6 mg/kg IV in D5W over 10-20 minutes (loading dose), the 0.4-1.0 mg/kg/hr, as needed or Terbutaline 0.25-0.50 mg IM/SC
  • Call for help for severe bronchospasm (if O2 Sat persistently less than 90%), transfer to ICU as indicated

Hypotension with Tachycardia

  • Trendelenberg position or elevate legs
  • IV placement, Monitor (Rhythm, Blood Pressure, Pulse Oximetry), and EKG
  • Oxygen (6-10L/min)
  • Rapid bolus of large volumes of normal saline (NS)
  • If poorly responsive, give Epinephrine (1:10,000) 1mL slowly IV (equivalent to 0.1mg) and up to 1 mg as needed

Hypotension with Bradycardia (Vasovagal Reaction)

  • Trendelenberg position or elevate legs
  • IV placement, Monitor (Rhythm, Blood Pressure, Pulse Oximetry), and EKG
  • Oxygen (6-10L/min)
  • Rapid bolus of large volumes of normal saline (NS)
  • Atropine 0.6-1.0mg IV slowly, Repeat atropine up to a total dose of 0.04 mg/kg (2-3mg in adult)

Hypertension, Severe

  • IV placement, Monitor (Rhythm, Blood Pressure, Pulse Oximetry), and EKG
  • Nitroglycerine 0.4mg tablet, sublingual (may repeat x 3), or topical 2% ointment, apply 1 inch strip
  • Sodium nitroprusside: solution must be diluted with 5% Dextrose before infusion; must maintain monitoring for decreases in blood pressure; infusion pump necessary to titrate
  • For pheochromocytoma - phentolamine 5.0mg (1.0mg in children) IV

Seizures or Convulsions

  • Oxygen (6-10L/min)
  • Consider Benzodiazepine such as Valium 5mg or Versed 0.5mg IV
  • If longer effect needed, obtain consultation from neurology; consider Dilantin infusion 15-18mg/kg at 50mg/min as indicated
  • Monitor (Rhythm, Blood Pressure, Pulse Oximetry) and call code team as indicated

Pulmonary Edema

  • Elevate Torso, rotating tourniquets (venous compression)
  • Oxygen (6-10L/min)
  • Administer Diuretics (for example, Lasix 40 mg IV, slowly pushed)
  • Consider morphine. Corticosteroids optional. Transfer to ER/ICU/CCU

References

  • ACR Manual on Contrast Media

Note

  • These guidelines are adapted based on references noted above. These are not absolute guidelines and all treatment strategies should be decided upon by physician and unique patient situation.

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